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    Home » Slugs usher in a more efficient wound healing process
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    Slugs usher in a more efficient wound healing process

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    Slugs usher in a more efficient wound healing process
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    In spite of the relentless technification of human society, Nature continues to be the best supply of inspiration when dealing with new challenges. Some time in the past, the seed of the burdock burr gave us the important thing to Velcro manufacturing whereas sharks gave us a grasp class on hydrodynamic swimsuit designing, to call a few. Our newest muse is a creature that, often, shouldn’t be thought-about because the embodiment of magnificence and concord. We are speaking concerning the Arion subfuscus, a easy slug which is a frequent dweller in many European gardens. What was the preliminary situation? The lack of adhesiveness of typical glues over damp human tissues, in addition to their toxicity, advised the event of more efficient alternate options concerning wound healing.

    A group of scientists from the Weyss Institute in collaboration with Harvard´s John A. Paulson School of Engineering and Applied Sciences observed that slugs, when underneath irritating circumstances, launched an especially sticky mucus able to retaining them firmly connected to virtually any sort of floor, even when moist. Dr. Jianyu Li, first contributor to the article revealed in Science journal describing the findings, realized that the substance excreted by slugs contained a matrix of positively charged proteins, able to producing an electrostatic attraction to surfaces that includes negatively charged particles. On prime of that, adhesion is ensured by covalent bonds and bodily interpenetration brought on by the fluid.

    After exploring these properties, they developed a blue hydrogel (the darker, the thicker) which, in addition to offering an adhesive functionality thrice greater than these parts getting used in Medicine up till now, launched a beforehand extraordinary ingredient. “The key feature of our material is the combination of a very strong adhesive force and the ability to transfer and dissipate stress, which have historically not been integrated into a single adhesive”, highlights Dave Mooney, one other of the proponents. This property is achieved when bonds between calcium atoms and hydrogel are damaged, thus dissipating the power when the fabric is underneath stress and offering it with greater resistance to torsion.

    The ensuing bio-glue has been efficiently examined on a number of pig tissues –corresponding to pores and skin, cartilage, liver and artery–, each moist and dry. The group has even used it to seal a gap in a pig coronary heart. “The glue adheres to a surface within three minutes, but then gets stronger. Within half an hour it is as strong as the body’s own cartilage”, Dr. Lin said. Tests carried out on rats demonstrated that the adhesive maintained its stability and bonding for weeks. Right now, they’re engaged on variations of the adhesive out of biodegradable supplies, in addition to on strategies to implement mass manufacturing.

    The glue developed by Lin and his group trails another medical adhesives just like the one devised by Gecko Biomedical, impressed in the mucous secretions of marine worms. This bio-glue is at the moment at take a look at stage and will develop into one other different to basic stitches.                                                                                          

    Biomimicry

    This bio-glue primarily based on the fluids of slugs and worms belongs to a self-discipline referred to as biomimicry that has led to many discoveries and innovations. It consists, primarily, in making use of strategies realized from Nature underneath the motto of emulation, not duplication, whereas drawing inspiration from its underlying rules. Biomimicry can function at various ranges, from a purely aesthetic or structural strategy to implications in the cell functioning of an organism. Mercedes-Benz, for example, took inspiration from a fish species –the well-known yellow boxfish starring in Finding Nemo – to design a automobile with optimum aerodynamic qualities.                                                                                        

    Sources: BBC, Science, Wyss Institute, Wired

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